Molecular and Cellular Mechanisms of Human Hypersensitivity and Autoimmunity

Molecular and Cellular Mechanisms of Human Hypersensitivity and Autoimmunity

4.11 - 1251 ratings - Source



A molecular and cellular biological approach to human immuno-deficiency and autoimmunity. Coverage includes descriptions of the cytokines and cellular mediators necessary for integrated and well-regulated immune responses. The antigenic stimuli, histocompatibility variants, lymphocytic defects and effector cell abnormalities central to selected human hypersensitivity and autoimmune diseases are also covered, as are molecular strategies to novel therapies for immune diseases using monoclonal antibodies or receptor-specific immunotoxins.Recent reports have identified two unrelated ADA-deficient patients who express no ADA-specific mRNA [9, 10]. Markert et al. ... This deletion is the consequence of homologous recombination between two repetitive DNA sequences of the Alu family. Detailed ... These deletion mutations clearly result in absence of transcription and total ADA deficiency. ... correspond to a normal, 1.5 kb message and a 1.25 kb fragment that may result from an RNA loop at the junction of exons 3 and 4.


Title:Molecular and Cellular Mechanisms of Human Hypersensitivity and Autoimmunity
Author: Edward J. Goetzl
Publisher:Alan R. Liss - 1989
ISBN-13:

You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.

Once you have finished the sign-up process, you will be redirected to your download Book page.

How it works:
  • 1. Register a free 1 month Trial Account.
  • 2. Download as many books as you like (Personal use)
  • 3. Cancel the membership at any time if not satisfied.


Click button below to register and download Ebook
Privacy Policy | Contact | DMCA