Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain

Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain

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Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. In the last century however, new discoveries have demonstrated the real existence of proliferation in the adult brain, and in the last decade, these studies led to the identification of neural stem cells in mammals. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons. Newly formed neurons terminally differentiate into mature neurons in the olfactory bulb and the dentate gyrus of the hippocampus. Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of brain stem cells. As a result, new therapies are successfully being applied to animal models for certain neurodegenerative diseases or stroke. At present, and in years to come, this finding extends to the adult human brain, and gives reason and hope to all the previous studies.In contrast to what happens in mice, ependymal cells are positive for nestin and BLBP (brain lipid-binding protein). ... by DiI in vitro tracing studies that revealed small bipolar cells in the glial layer at a distance from the site of the label deposit. ... of the rabbit subependyma are almost indistinguishable from the rodent SVZ, the rabbit brain shows certain peculiarities. ... that proliferate very slowly, and ependymal cells (gray) that do not divide. c After a few days (14 days in the diagram), theanbsp;...


Title:Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain
Author: Sara García Gil-Perotin, Arturo Alvarez-Buylla, Jose Manuel Garcia-Verdugo
Publisher:Springer Science & Business Media - 2009-04-21
ISBN-13:

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