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Alternatives to Laboratory Animals ... This will also require regulators to specify which species are considered suitable for testing particular chemical classes. ... As pointed out by the APC, it is known that humans and primates display similar pharmacokinetic profiles and ... since gene expression levels in key organs and tissues can differ significantly in humans and other primates (9, 10). ... Hence, it is unlikely that genomics analysis alone could be used to guide species selection.

Publisher: - 2005

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